My research interests span a wide range of topics within the malaria field, with particular emphasis on the hepatic stage of infection. In general terms, I am interested in elucidating hitherto obscure aspects of the biology of Plasmodium infection, unveiling novel host-parasite interactions and developing new drug- and vaccine-based anti-malarial strategies, and developing new hepatic Plasmodium infection systems.
Specifically, my current research focuses on:
Unraveling novel host-parasite molecular interactions during Plasmodium hepatic infection.
Understanding the molecular mechanisms of nutrient uptake and metabolism during Plasmodium development inside hepatic cells.
Investigating the reciprocal influence of Plasmodium and Trypanosoma co-infections.
Developing and evaluating the activity of novel compounds against Plasmodium liver stages.
Developing a novel pre-erythrocytic whole-organism anti-malarial vaccination strategy.
Developing effective in vitro sporozoite production and sporozoite cryopreservation methods.
Developing a new 3D hepatic cell culturing system for Plasmodium infection.